Coltrix Cartiregen

What Is Collagen?

Collagen is found in the main structural protein of various connective tissues in animals and humans.
As the main component of connective tissue, it is the most abundant protein in mammals and accounts for approximately 25% to 35% of total body protein content.

Collagen is most commonly found in elongated fibrillar form in fibrous tissues such as tendons, ligaments, and skin. It is also abundant in corneas, cartilage, bones, blood vessels, intestines, intervertebral discs, and dentin tissue. In muscle tissue, it serves as one of the main components of the endomysium.
Collagen makes up 1–2% of muscle tissue and 6% of the weight of strong, inclined muscles. Fibroblasts are the most common cells that produce collagen.
Important facts about collagen

– Approximately 30% of all proteins in the human body are collagen.

– More than 90% of the collagen in the body is type 1. Type 1 collagen fibrils are stronger than steel.

– Collagen is found mostly in the skin, bones, and connective tissues.

– Collagen gives the skin both strength and elasticity and is also responsible for the renewal of dead skin cells.

– Collagen production in the body typically begins to decrease after the age of 40.

– Medical-grade collagen can be obtained from human, bovine, porcine, and small ruminant sources.

– Collagen dressings attract new skin cells to wound areas.

– Cosmetic products such as revitalizing lotions claim to increase collagen levels. However, such claims are highly questionable because collagen molecules are too large to be absorbed through the skin.

– Collagen production in the body can be stimulated with laser therapy.

What is Coltıx Cartiregen?

Coltıx Cartiregen® is 3% Type-I atelocollagen, synthesized inside the cell as individual pro-chains, each with an N-terminal and C-terminal propeptide, to help form a tightly packed triple-helix structure. It is involved in region-specific interactions that facilitate the formation of collagen and collagen fibrils, as well as in the cross-links required for fibril stabilization. Removal of the telopeptide regions allows for reduced antigenicity of this product.

Collagen, classified and refined according to medical grades, is a natural material compatible with living bodies, in which immune rejection reactions are minimized by removing the telopeptide portion containing an antigen. Collagen transplanted into a living body functions as a three-dimensional biological scaffold, prevents the loss of cells migrating into the scaffold, and helps tissue regeneration. Cell-friendly collagen can be used as a material for tissue regeneration or replacement, and it is also applied in various fields as a carrier for medical substances, hemostatic materials, cosmetic raw materials, and more.
Currently, research into biocompatible medical devices that can function semi-permanently in the human body is highly active. High-purity collagen for medical use can be applied to various areas of the human body, not only as a single raw material but also by mixing it with other materials compatible with living bodies; therefore, its scope of application is expanding.

Ubiosis Co., Ltd. has developed and is currently selling collagen tissue replacement materials for bone, cartilage, tendons, ligaments, muscles, and biological membranes. Based on raw materials produced in Korea and together with its developed compression enrichment method, the company is now expanding the application areas of its products to include wound healing, artificial skin, burn treatment, corneal protective materials, cosmetics, and more.

Delivery
Coltıx Cartiregen Collagen is supplied in a prefilled sterile syringe containing 1 mL of 3% collagen gel. The only excipient in this translucent, sterile gel is phosphate-buffered saline at pH 7.

Storage
Coltıx Cartiregen Collagen is easy to store. It should be stored in a cool, dry place between 1° and 30°C, away from sunlight. Product stability for COLTRIX Collagen is 2 years.